Mehmet Toner, PhD

Founding Co-Director, The Center for Surgery, Innovation & Bioengineering

A Division in Surgery at the Massachusetts General Hospital

Helen Andrus Benedict Professor of Biomedical Engineering

Harvard Medical School

Founding Director, BioMEMS Center

Massachusetts General Hospital

Mehmet is internationally recognized for his multidisciplinary approaches to biomedical problems in the areas of low-temperature biology, tissue engineering and artificial organs, and microsystems bioengineering in clinical medicine and biology, as well as nanotechnology in clinical medicine and global health. Mehmet is a member of the Board of Trustees of Özyeğin University, and served as a member of the President’s Council of Olin College of Engineering and son the Board of the National Science Foundation Engineering Directorate. He has received many prestigious awards including the H.R. Lissner Medal from the American Society of Mechanical Engineering. He was selected to become a Fellow of the American Institute of Medical and Biological Engineering, a Fellow of the American Society of Mechanical Engineers, and a Fellow of the Society for Cryobiology. Mehmet received a BS from Istanbul Technical University and a MS from MIT, both in Mechanical Engineering. He completed his PhD in Medical Engineering at the Harvard-MIT Division of Health Sciences and Technology.

Representative publications

Yu M, Bardia A, Aceto N, Bersani F, Madden MW, Donaldson MC, et al. Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility. Science. 2014 Jul; 345(6193):216-20. PubMed PMID: 25013076

Berendsen TA, Bruinsma BG, Puts CF, Saeidi N, Usta OB, Uygun BE, et al. Supercooling enables long-term transplantation survival following 4 days of liver preservation. Nat Med. 2014 Jul; 20(7):790-3. 
PubMed PMID: 24973919; PubMed Central PMCID: PMC4141719

Lim EJ, Ober TJ, Edd JF, Desai SP, Neal D, Bong KW, et al. Inertio-elastic focusing of bioparticles in microchannels at high throughput. Nat Commun. 2014; 5:4120. 
PubMed PMID: 24939508

Karabacak NM, Spuhler PS, Fachin F, Lim EJ, Pai V, Ozkumur E, et al. Microfluidic, marker-free isolation of circulating tumor cells from blood samples. Nat Protoc. 2014 Mar; 9(3):694-710. PubMed PMID: 24577360; PubMed Central PMCID: PMC4179254

Ozkumur E, Shah AM, Ciciliano JC, Emmink BL, Miyamoto DT, Brachtel E, et al. Inertial focusing for tumor antigen-dependent and -independent sorting of rare circulating tumor cells. Sci Transl Med. 2013 Apr; 5(179):179ra47. 
PubMed PMID: 23552373; PubMed Central PMCID: PMC3760275

Yu M, Bardia A, Wittner BS, Stott SL, Smas ME, Ting DT, et al. Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition. Science. 2013 Feb; 339(6119):580-4. 
PubMed PMID: 23372014; PubMed Central PMCID: PMC3760262

Liong M, Hoang AN, Chung J, Gural N, Ford CB, Min C,et al. Magnetic barcode assay for genetic detection of pathogens. Nat Commun. 2013; 4:1752. 
PubMed PMID: 23612293; PubMed Central PMCID: PMC3635151

El-Haibi CP, Bell GW, Zhang J, Collmann AY, Wood D, Scherber CM, et al. Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy. Proc Natl Acad Sci U S A. 2012 Oct; 109(43):17460-5. PubMed PMID: 23033492; PubMed Central PMCID: PMC3491529

Yu M, Ting DT, Stott SL, Wittner BS, Ozsolak F, Paul S, et al. RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis. Nature. 2012 Jul; 487(7408):510-3. 
PubMed PMID: 22763454; PubMed Central PMCID: PMC3408856

Aldridge BB, Fernandez-Suarez M, Heller D, Ambravaneswaran V, Irimia D, Toner M, et al. Asymmetry and aging of mycobacterial cells lead to variable growth and antibiotic susceptibility. Science. 2012 Jan; 335(6064):100-4. PubMed PMID: 22174129; PubMed Central PMCID: PMC3397429


Mehmet Toner, Ph.D.
Massachusetts General Hospital
Center for Engineering in Medicine, Room 1401
114 16th Street 
Charlestown MA 02129

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