Ronald G. Tompkins, MD, ScD

Founding Director, The Center for Surgery, Innovation & Bioengineering

A Division in Surgery at the Massachusetts General Hospital

Sumner M. Redstone Professor of Surgery

Harvard Medical School

Division Chief, Surgery, Science & Bioengineering

Massachusetts General Hospital

Ron is internationally recognized for his work in clinical systems biology particularly as it relates to inflammation and metabolism in the fields of genomics, proteomics, and computational biology. His collaborative track record has secured more than $200 million in federal, foundation, and industrial support for basic and clinical research programs. Ron has been the principal investigator of a P50 award and a T32 Burn Research Training Grant for 25 years and a U54 program for ten years that developed the clinical infrastructure to study critically ill trauma populations, as well as the technological and bioinformatics skills to isolate leukocyte populations and probe the transcriptome as it responds to severe injury. The development of clinical treatment protocols by consensus of the trauma and burn centers participating in this “Glue Grant” program led to improvements in survival, reduction in morbidity for injured patients, and established benchmarks for care in the fields of burns and trauma. He is a Fellow of the American Institute of Medical and Biological Engineering. Ron graduated from Tulane University School of Medicine and received his training in general surgery at MGH. He earned an SM and ScD degrees in chemical engineering from MIT.

Representative Publications

Seok J, Warren HS, Cuenca AG, Mindrinos MN, Baker HV, Xu W, et al. Genomic responses in mouse models poorly mimic human inflammatory diseases.  Proc Natl Acad Sci U S A. 2013 Feb; 110 (9):3507-12. PubMed PMID: 23401516; PubMed Central PMCID: PMC3587220

Xiao W, Mindrinos MN, Seok J, Cuschieri J, Cuenca AG, Gao H, et al. A genomic storm in critically injured humans. J Exp Med. 2011 Dec; 208(13):2581-90. PubMed PMID: 22110166; PubMed Central PMCID: PMC3244029

Xu W, Seok J, Mindrinos MN, Schweitzer AC, Jiang H, Wilhelmy J, et al. Human transcriptome array for high-throughput clinical studies. Proc Natl Acad Sci U S A. 2011 Mar; 108(9):3707-12. PubMed PMID: 21317363; PubMed Central PMCID: PMC3048146

Kotz KT, Xiao W, Miller-Graziano C, Qian WJ, Russom A, Warner EA, et al. Clinical microfluidics for neutrophil genomics and proteomics. Nature Medicine. 2010 Sep; 16(9):1042-7. PubMed PMID: 20802500; PubMed Central PMCID: PMC3136804

Zhou B, Xu W, Herndon D, Tompkins R, Davis R, Xiao W, et al. Analysis of factorial time course microarrays with application to a clinical study of burn injury. Proc Natl Acad Sci U S A. 2010 Jun; 107(22):9923-8. PubMed PMID: 20479259; PubMed Central PMCID: PMC2890487

Stott SL, Lee RJ, Nagrath S, Yu M, Miyamoto DT, Ulkus L, et al.  Isolation and characterization of circulating tumor cells from localized and metastatic prostate cancer patients. Sci Transl Med. 2010 Mar; 2(25):25ra23. PubMed PMID: 20424012; PubMed Central PMCID: PMC3141292

Information

Ronald G. Tompkins, M.D., Sc.D.
Massachusetts General Hospital
55 Fruit Street
Boston, MA  02114

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