Nima Saeidi, PhD

Assistant Professor

Department of Surgery

Harvard Medical School

Assistant in Bioengineering

Massachusetts General Hospital

Dr. Saeidi is currently an Assistant Professor at Harvard Medical School and Massachusetts General Hospital. He received his BSc in Mechanical Engineering and Physics from Sharif University of Technology (Tehran, Iran) in 2003, followed by MSc in Mechanical Engineering and PhD in Bioengineering from Northeastern University in 2005 and 2005, respectively. He joined the Center for Engineering in Medicine in at Massachusetts General Hospital and Harvard Medical School in 2010 as a postdoctoral fellow.

Dr. Saeidi’s current research has two primary thrusts. The first thrust is in the area of metabolism and obesity, where he is interested in understanding the mechanisms underlying regulation of energy homeostasis with strong emphasis towards identification of therapeutic targets and development of novel treatment for metabolic disorders. A major focus of this thrust is aimed at using the rodent models of bariatric surgery to delineate the mechanisms that mediate the body weight loss and resolution of diabetes following these operations, and use this unique platform to identify novel targets for development of non-surgical treatments for obesity and diabetes. The second thrust is in the area of biomimetic materials and tissue engineering, where he employs the crowding-confining-induced molecular self-assembly method that he has recently developed to recreate the intricate structure of native tissues. Presently, the primary focus of this thrust is aimed at tissue engineering of cornea and annulus fibrosus. Dr. Saeidi’s research has been published is the leading scientific journals including Science, Biomaterials, Nature Medicine, and Tissues Engineering, and has been extensively featured by NIH Director’s Blog, Nature News & Views, BBC, Boston Globe, among others.

Representative publications

Saeidi N, Meoli L, Nestoridi E, Gupta NK, Kvas S, Kucharczyk J, et al. Reprogramming of intestinal glucose metabolism and glycemic control in rats after gastric bypass. Science. 2013 Jul; 341(6144):406-10. PubMed PMID: 23888041; PubMed Central PMCID: PMC4068965

Saeidi N, Guo X, Hutcheon AEK, Sander EA, Bale SS, Melotti SA, et al. Disorganized collagen scaffold interferes with fibroblast mediated deposition of organized extracellular matrix in vitro. Biotechnology and Bioengineering. 2012 Oct; 109(10):2683-98. PubMed PMID: 22528405; PubMed Central PMCID: PMC3757098

Saeidi N, Nestoridi E, Kuczarczyk J, Uygun K, Yarmush ML, Stylopoulos  N. Sleeve gastrectomy and roux-en-y gastric bypass exhibit differential effects on food preferences, nutrient absorption and energy expenditure in obese rats. International Journal of Obesity. 2012 Nov; 36(11):1396-402. PubMed PMID: 23044855; PubMed Central PMCID: PMC3651693

Saeidi N, Karmelek KP, Paten JA, Zareian R, Dimasi E, Ruberti JW. Molecular crowding of collagen: a pathway to produce highly-organized collagenous structures. Biomaterials. 2012 Oct; 33(30):7366-74. PubMed PMID: 22846420; PubMed Central PMCID: PMC3757096

Saeidi N, Sander EA, Zareian R, Ruberti JW. Production of highly-aligned collagen lamellae by combining shear force and thin-film confinement. Acta Biomaterialia. 2011 Jun; 7(6):2437-47. PubMed PMID: 21362500; PubMed Central PMCID: PMC3712118

Information

Nima Saeidi, Ph.D.
Shriners Hospital for Children
51 Blossom St., Rm. 266
Boston, MA 02114

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Grace McDonald-SmithNima Saeidi, PhD