Dr. Jindal earned his integrated BS and MS degree in Biochemical Engineering and Biotechnology from Indian Institute of Technology Delhi.  He holds a PhD in Chemical and Biological Engineering from Rensselaer Polytechnic Institute.  During his graduate research, he developed approaches for creating multifunctional microfluidic devices with special emphasis on incorporating chromatography in lab-on-a-chip devices. After finishing his Ph.D., he joined Massachusetts General Hospital as a postdoctoral fellow where his research spanned several areas including 3D model of liver tissue, liver steatosis,  inflammatory pathways involved in endothelium activation, and drug-induced liver injury.  Upon completion of his postdoctoral training, he joined Rutgers University as a Research Associate/Scientist on a L’Oreal funded project with the overall goal of creating a microfabricated platform as an alternative to animal testing for analyzing allergic reactions to chemicals.  He returned to MGH as an Instructor in Surgery and Bioengineering. His current research interests include creating liver tissue systems for drug toxicity testing and as models for various disease conditions including NASH/ASH and HCV/HIV infection.

Representative publications

Hegde M, Jindal R, Bhushan A, Bale SS, McCarty WJ, Golberg I, Usta OB, Yarmush ML “Dynamic interplay of flow and collagen stabilizes primary hepatocytes culture in a microfluidic platform” Lab on a chip, 2014, 14, 2033-2039.

Mitra B, Jindal R, Lee S, Dong D, Li L, Sharma N, Maguire T, Schloss R,  Yarmush ML “Microdevice integrating innate and adaptive immune responses associated with antigen  presentation by dendritic cells” RSC Advances, 2013, 3, 16002-16010.

Patel SJ, Milwid JM, King KR, Bohr S, Iracheta A, Li M, Vitalo A, Wu FJ, Parekkadan B, Jindal R, Yarmush ML “Gap junction inhibition prevents drug-induced liver toxicity and fulminant hepatic failure”, Nature Biotechnology, 2012, 30, 179-183.

Jindal R, Patel SJ, Yarmush ML “Tissue engineered model for real time monitoring of liver inflammation” Tissue Engineering Part C Methods, 2011, 17: 113-122.

Patel SJ, Jindal R, King KR, Tilles AW, Yarmush ML “The Inflammatory Response to double stranded DNA in endothelial cells is mediated by NFκB and TNFα”, PloS ONE, 2011, 6(5): e19910

Jindal R, Nahmias Y, Tilles AW, Berthiaume F, Yarmush ML “Amino acid mediated heterotypic interaction governs performance of a hepatic tissue model”  FASEB J, 2009 23: 2288-2298.

Berthiaume F, Barbe L, Mokuno Y, MacDonald A, Jindal R, Yarmush ML “Steatosis reversibly increases hepatocyte sensitivity to hypoxia-reoxygenation injury” J Surgical Research, 2009, 152: 54-60.

Information

Rohit Jindal, Ph.D.
Instructor in Surgery and Bioengineering
Center for Engineering in Medicine
Massachusetts General Hospital
51 Blossom Street
Boston, MA 02114

View Rohit’s Harvard Catalyst profile