Martin Yarmush, MD, PhD

Founding Co-Director, The Center for Surgery, Innovation & Biotechnology

A Division in Surgery at the Massachusetts General Hospital

Founding Director, Center for Engineering in Medicine

Massachusetts General Hospital

Lecturer in Surgery and Bioengineering

Harvard Medical School

Maish is the founding Director of the Center for Engineering in Medicine at MGH, which is an essential component of the Center. Originally established in 1995, and catapulted with a $5M Whitaker Foundation Development Award in 1997, the CEM has developed an international reputation as a pre-eminent training venue for young bioengineers, and a cutting edge research enterprise specializing in the intersection of the molecular and cellular sciences and microsystems bioengineering. Maish is a recognized leader and pioneer in the fields of tissue engineering and regenerative medicine, applied immunology, clinically- and industrially-relevant bioengineered microsystems, genomics and proteomics technologies, and metabolic engineering. His research pushes the envelope on several healthcare technology frontiers, and he has been credited with many pioneering scientific and technological advances that have resulted in numerous patents and the formation of more than 10 companies. Maish has published more than 480 refereed journal articles; has advised and mentored more than 90 postdoctoral fellows and more than 40 graduate students; and has taught a spectrum of courses from molecular genetics and immunology to thermodynamics and transport phenomena. More than 70 of his former fellows have gone on to successful careers in academia both here and abroad, and several others have gone on to become leaders in the Biotechnology and Medical Device industries. He has contributed to the advancement of science and engineering through service on various panels, foundation and academic advisory boards, and as editor of numerous science and engineering journals. Maish has also been a frequent invited speaker at major conferences and institutions with more than 30 national and local awards. Maish received BA degrees in Biology and Chemistry from Yeshiva University, an MD from Yale, and PhD degrees from Rockefeller (Biophysical Chemistry and Immunology) and MIT (Chemical Engineering). From 1995 to 2008, he was the Helen Andrus Benedict Professor of Surgery and Bioengineering at Harvard Medical School.

Representative publications

Uygun BE, Soto-Gutierrez A, Yagi H, Izamis ML, Kobayashi N, Tilles AW, et al. Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix. Nat Med. 2010 Jul; 16(7):814-20. PubMed PMID: 20543851; PubMed Central PMCID: PMC2930603.

Koria P, Yagi H, Megeed Z, Nahmias Y, Sheridan R, Yarmush ML. Self-assembling elastin-growth factor chimeric nanoparticles for the treatment of chronic wounds. Proc Natl Acad Sci U S A. 2011 Jan; 108(3):1034-9. PubMed PMID: 21193639; PubMed Central PMCID: PMC3024670.

Patel SJ, Milwid JM, King KR, Li M, Parekkadan B, YarmushML.  Engineering a hepatoprotective strategy for preventing drug-induced liver toxicity. Nat Biotechnol. 2012 Jan; 30(2):179-83. PubMed PMID: 22252509; PubMed Central PMCID: PMC3609650

Lee J, Li M, Milwid J, Dunham J, Vinegoni C, Gorbatov R, et al. Implantable microenvironments to attract hematopoietic stem/cancer cells. Proc Natl Acad Sci U S A. 2012 Nov; 109(48):19638-43. PubMed PMID: 23150542; PubMed Central PMCID: PMC3511730

Bohr S, Patel SJ, Shen K, Brines M, Cerami A, Berthiaume F, et al. Alternative erythropoietin-mediated signaling prevents secondary microvascular thrombosis and inflammation within cutaneous burns. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3513-8. PubMed PMID: 23401545; PubMed Central PMCID: PMC3587271.

Saeidi N, Meoli L, Kvas S, Kucharczyk J, Gupta NK, Nestoridi E, et al. Intestinal metabolic reprogramming improves glycemic control by enhanced GLUT-1-dependent glucose uptake and utilization. Science. 2013 Jul; 341(6144):406-10. PubMed PMID: 23888041; PubMed Central PMCID: PMC4068965

Berendsen TA, Bruinsma BG, Puts CF, Saeidi N, Usta BO, Uygun B, et al. Successful supercooled liver storage for 4 days. Nat Med. 2014 Jul; 20(7):790-3. PubMed PMID: 24973919; PubMed Central PMCID: PMC4141719

Information

Martin L. Yarmush, M.D., Ph.D.
Massachusetts General Hospital
51 Blossom Street
Boston, MA  02114

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Ronald TompkinsMartin L. Yarmush, MD, PhD